Kevin Hancock scored the game winner on the power play in the third and Owen Sound edged Erie 2-1.
Daylon Groulx scored the equalizer just 40 seconds into the second period after the Otters took a 1-0 lead in the first.
Despite the loss, Otters' netminder Daniel Murphy earned first star honours with a 49 save performance. Mack Guzda had to stop just 21 shots for the Attack.
Owen Sound is back in action tonight when they visit the Niagara Ice Dogs.