Two people were sent to the hospital after a single-vehicle crash on Perth Line 43.
Emergency services attended the crash on Saturday shortly before 11 a.m.
Two people were transported to hospital; one with life-threatening injuries, the other with minor injuries.
OPP Technical Collision Investigators (TCI) are currently assisting.
OPP closed Perth Line 43 between Perth Roads 107 and 108 around 11:14 a.m. as the investigation continued. The roadway was re-opened around 5:35 p.m.
Motorists are asked to avoid the area. Updates will be provided when available.
Anyone with information is asked to contact OPP at 1-888-310-1122. Should you wish to remain anonymous, you may contact Crime Stoppers at 1-800-222-8477 (TIPS), or online www.hc-cs.ca, where you may be eligible to receive a cash reward of up to $2000.00.