Plympton-Wyoming is the first municipality in Lambton County to opt out of retail cannabis sales.
Council voted 4-3 in favour of keeping the legal pot shops out of the town at its meeting last week.
Mayor Lonny Napper said many local residents didn't want them in the community.
"They didn't see any place in Wyoming that it would really fit in," said Napper. "It was a decision of council, and they feel that people have other communities they can go to and buy it if they want and there are online sales coming through the post office. We only have one or two blocks of commercial sales in the town, and they didn't think it was a good fit along there."
Meanwhile, Sarnia council voted to opt into retail cannabis sales at its December meeting.
Municipalities are required to make a decision by January 22 to be eligible to operate a store beginning April 1, 2019.
However, the chances of getting a licence will still be difficult.
The Progressive Conservatives say only 25 licences will be issued by April, because of what it calls "severe supply shortages" across the country.
